The relationship of tumor necrosis to white blood cell changes in the hamster.
نویسنده
چکیده
In a previous publication it was pointed out that definite relationships existed between the growth curve of a 100 per cent transplantable methylcholanthrene-induced hamster sarcoma and several blood cell factors (1~). As the tumor grew in the hamster cheek pouch, characteristic alterations were noted in the levels of hemoglobin, red and white blood cells, differential white blood cell counts, hematocrits, sedimentation rates, and in platelet determinations. I t was speculated that the elevated white blood cell counts and sedimentation rates and the reversed neutrophil to lymphocyte ratios were associated with the presence of tumor necrosis, which occurred at an early stage in the growth of the tumor but did not become apparent externally until a later time in the tumor growth cycle. I t was the purpose of this study to determine whether these alterations in the white blood cells and sedimentation rates could be produced by the products of tumor necrosis in the absence of viable tumor.
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ورودعنوان ژورنال:
- Cancer research
دوره 19 5 شماره
صفحات -
تاریخ انتشار 1959