The relationship of tumor necrosis to white blood cell changes in the hamster.

نویسنده

  • J D SHERMAN
چکیده

In a previous publication it was pointed out that definite relationships existed between the growth curve of a 100 per cent transplantable methylcholanthrene-induced hamster sarcoma and several blood cell factors (1~). As the tumor grew in the hamster cheek pouch, characteristic alterations were noted in the levels of hemoglobin, red and white blood cells, differential white blood cell counts, hematocrits, sedimentation rates, and in platelet determinations. I t was speculated that the elevated white blood cell counts and sedimentation rates and the reversed neutrophil to lymphocyte ratios were associated with the presence of tumor necrosis, which occurred at an early stage in the growth of the tumor but did not become apparent externally until a later time in the tumor growth cycle. I t was the purpose of this study to determine whether these alterations in the white blood cells and sedimentation rates could be produced by the products of tumor necrosis in the absence of viable tumor.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of Brain Natriuretic Peptide, Tumor Necrosis Factor and Interleukin-6 Plasma Levels in Infants and Children with Congenital Heart Disease

Background Congenital heart disease (CHD) is the most common cause of major congenital birth defect. The aim of this study was to investigate the association of CHD with serum levels of Tumor necrosis factor-α (TNFα), Interleukin 6 (IL-6), and B-type Natriuretic Peptide (BNP) in infant and children. Materials and Methods The present study was conducted in Heshmat heart hospital and 17 Shahrivar...

متن کامل

Spontaneous differentiated squamous cell carcinoma of cheek pouch in a Syrian hamster

A 2-year-old male hamster was presented because of left facial swelling and salivation. Necropsy wasperformed and affected cheek pouch with tissue samples of regional and internal organs were submitted forhistopathological study. In histopathological examination it was found that the tumor consisted of cords andislands of tumoric epithelial cells which were diffused in the dermis. Vacoulation o...

متن کامل

Systemic Amyloidosis and Testicular Interstitial Tumor in a Zebra Finch (Taeniopygia guttata): a Case Report in Iran

Systemic amyloidosis and testicular interstitial tumor are rare conditions in birds and this is the first report in Iran. A male zebra finch was presented because of white diarrhea, anorexia, loss of weight and lethargy. At necropsy, the small intestine was edematous and congested. The spleen appeared pale. The liver was large, firm and brown. One testis was cystic and neoplastic and the remain...

متن کامل

Evaluation of total and differential white blood cell counts in workers exposed to lead

Introduction: Lead is a toxic heavy metal that has adverse health effects on blood parameters. About 80% of lead produced is used in batteries, especially vehicle batteries. Therefore, the present study aimed to assess the hematological changes, including total and differential white blood cell (WBC) counts in battery workers exposed to lead, and compare with the non-exposed group. Materials a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Cancer research

دوره 19 5  شماره 

صفحات  -

تاریخ انتشار 1959